Search results for " Dupuytren"
showing 3 items of 3 documents
Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren’s disease
2016
The mechanism by which the fibroblast is able to trigger palmar fibromatosis is still not yet fully understood. It would appear certain that the “abnormal” fibroblasts continuously synthesise profibrotic cytokines which are able to determine the activation to myofibroblasts, to stimulate them to the further proliferation and synthesis of other cytokines, to modify the cells’ differentiation and ultrastructural characteristics, as well as the production of matrix and other proteins. Several fibroblast growth factors have been suggested to be responsible of an abnormal cell activation with an aberrantly elevated collagen synthesis and extracellular deposition in Dupuytren’s disease, as TGF-Be…
Treatment of stages IIIIV of the Dupuytrens Disease using a personal approach: percutaneous needle fasciotomy (PNF) and minimal invasive selective ap…
2013
Abstract The authors present their experience in treating 23 fingers on 20 patients affected by Dupuytrens Disease in stages III and IV of the Tubiana classification with their personal technique that involves the percutaneous needle fasciotomy followed 40 days after by a selective open aponeurectomy on the previously treated cord, by making a small cutaneous incision. The treatment requires careful selection of the patients. In fact, patients suffering from the disease for more than 5 years and all the cases with a suspicion of joint rigidity are excluded from the study. The average follow up period was approximately 48 months. 18 out of the 20 patients had excellent functional recovery. S…
Malattia di Dupuytren
2012
La malattia di Dupuytren ancora oggi rimane avvolta nel mistero: è incerta la paternità della sua prima descrizione, sebbene, e con molte polemiche, da centoottantuno anni è storicamente legata all’illustre chirurgo francese Guillaume Dupuytren. Un enigma per gli studiosi è anche la sua eziopatogenesi, in cui fattori ambientali, comportamentali, genetici, e biomolecolari, in parte ancora sconosciuti, interagiscono a più livelli, generando reazioni biochimiche a cascata che portano alla ben nota iperproliferazione dei fibroblasti e alla conseguente deposizione di collagene. Essa rappresenta inoltre una sfida per il chirurgo che deve districarsi tra tecniche operatorie differenti in relazione…